Across:
1. 2015-'20 TV hip-hop musical drama: EMPIRE.
7. Toyota sedans: AVALONS.
14. Outer organ layer: CORTEX.
15. Email staple: EMOTICON.
16. Pooh-pooh, with "at": SNEEZE.
17. Michelangelo's "David," for one: MALE NUDE.
18. Do something to hide?: TAN.
19. Devoted: ARDENT.
21. Name on the 1949 "Death of a Salesman" playbill: ELIA.
22. Bad news word: ALAS.
24. Thrice, in prescriptions: TER.
25. Nosh: SNACK.
26. Proportional gift: TITHE.
28. Extreme distress: AGONY.
31. "Curious George" co-author Margret: REY.
32. Start of a "Huh?" response: ISAID.
33. Fix up, as an old pool: RELINE.
35. Comics characters in "Homicidal Psycho Jungle Cat": CALVIN AND HOBBES.
40. Duck soup: ACINCH.
41. Exmoor heroine: DOONE.
42. Part of the 56-Across: SIB.
45. Tucker of country: TANYA.
46. Warblers' warbles: SONGS.
47. Law school beginners: ONELS.
49. High-__: upscale: END.
51. __ Sea: Arctic Ocean arm: KARA.
52. Cut with light: LASE.
53. It was delayed three months in 2020: TAXDAY.
56. See 42-Across: FAM.
57. Apple Pencil go-with: iPAD MINI.
59. "Honest!": NO JIVE.
61. Try-before-you-buy item: DEMO UNIT.
62. Ace of Base, e.g.: SWEDES.
63. "The Mets have shown me more ways to lose than I even knew existed" speaker: STENGEL.
64. First arrival: ELDEST.
Down:
1. Stoked: ECSTATIC.
2. 16th-century masterpiece: MONA LISA.
3. Like most OB visits: PRENATAL.
4. Mineral ending: ITE.
5. Exiled Shah Mohammad __ Pahlavi: REZA.
6. Bring into play: EXERT.
7. Start of many bar jokes: AMAN.
8. Electric Chevy: VOLT.
9. Put away: ATE.
10. Bedding: LINEN.
11. Concerned with pupils?: OCULAR.
12. "Fat chance": NO DICE.
13. Disingenuous: SNEAKY.
15. Way away from danger: EMERGENCY EXIT.
20. Start of a request for advice: DEAR ANN.
23. Hindu deity: SHIVA.
25. Clerical assemblies: SYNODS.
27. Royal commands: EDICTS.
29. Warhorse: OLD HAND.
30. Org. studying epidemics: NIH.
34. Digital read: E-BOOK.
36. Vardalos of "My Big Fat Greek Wedding": NIA.
37. Real: BONAFIDE.
38. Cuts in lines: ENGRAVES.
39. Fictional NYC thoroughfare: SESAME ST.
42. Big favors, in slang: SOLIDS.
43. Ticked: IN A PET.
44. "__ Mucho": 1944 #1 song: BESAME.
48. Conned: LED ON.
50. "__ avec les stars": DANSE.
53. Pointed part: TINE.
54. Indigo dye: ANIL.
55. Wail: YOWL.
58. Travel __: MUG.
60. Clampett patriarch: JED.